Can you combine microdosing with weed?

Benefits of combining microdosing truffles and weed:

  1. Enhanced creativity: Some people find that smoking weed before or after microdosing truffles can enhance their creativity and open up new pathways in their thinking. This is because both substances can alter your perception of reality and help you think outside of the box.
  2. Amplified effects: Weed can amplify the effects of microdosing truffles, making the experience more intense and potentially more transformative. This can be especially beneficial for those who are looking for a deeper spiritual experience or a greater sense of connectedness.
  3. Relief from anxiety: Weed can have a calming effect and may help to counteract any anxiety or nervousness that can arise from taking psychedelics. This can be especially helpful for those who are new to microdosing or who tend to feel anxious or uncomfortable during psychedelic experiences.
  4. Pain relief: Weed is known for its analgesic properties and may help to alleviate any physical pain or discomfort that you may experience during or after microdosing truffles.
  5. Improved mood: Both weed and truffles have been shown to have mood-enhancing effects, so combining the two may lead to an even greater sense of well-being and positivity.

Risks of combining microdosing truffles and weed:

  1. Overwhelming effects: Combining weed and truffles can lead to an overwhelming experience, especially for those who are new to psychedelics. The intensity of the experience may be too much to handle and could lead to feelings of panic or anxiety.
  2. Anxiety and paranoia: While weed can help with anxiety, it can also exacerbate it in some cases. Combining it with microdosing truffles may increase the likelihood of experiencing anxiety or paranoia, especially if you are already prone to these feelings.
  3. Unpredictable effects: Everyone’s body chemistry is different, so it’s hard to predict how the combination of microdosing truffles and weed will affect each individual. Some people may have a positive experience, while others may experience negative side effects.
  4. Impaired judgment: Weed can impair your judgment and make it more difficult to make decisions or process information. This could be dangerous if you are operating heavy machinery or driving while under the influence of both substances.
  5. Negative interactions: If you are taking any medications or have any underlying health conditions, combining weed and truffles could lead to negative interactions or side effects. It’s important to talk to your healthcare provider before trying this combination.


In conclusion, combining microdosing truffles and smoking weed can have both potential benefits and risks. While it may enhance creativity, amplify effects, relieve anxiety and pain, and improve mood, it may also lead to overwhelming effects, anxiety and paranoia, unpredictable outcomes, impaired judgment, and negative interactions.

Therefore, it is crucial to approach the combination with caution and start with small doses of both substances. It is also important to pay close attention to how each substance affects you, especially if you are new to microdosing or have underlying mental health issues.

Moreover, it is essential to use them in a safe and responsible manner, ideally with the guidance of a healthcare professional or an experienced microdosing mentor.

If you decide to combine microdosing truffles and smoking weed, it is also recommended to use high-quality, lab-tested substances from a reputable source. Using lower quality or contaminated substances can lead to unpredictable effects and potentially harmful outcomes.

In summary, combining microdosing truffles and smoking weed is a personal choice that should be approached with care and responsibility. While it can enhance the positive effects of each substance, it can also lead to negative outcomes if not used properly. Therefore, it is essential to educate yourself on the risks and benefits, start with small doses, and use them in a safe and legal manner.

Do they find magic mushrooms and truffles during a drug test?

Can a drug test use magic detect mushrooms or truffles? And if so, how long after use? That’s what we researched, to explain to you exactly how using this affects a drug test.

Psilocybin in mushrooms and truffles

The mushrooms and truffles with psilocybin are popular in microdosing . The psychedelics were previously mainly used by psychonauts , but are now gaining a wider audience. But, how does the body deal with the psychoactive ingredients in it? And, can a drug test determine whether you used psilocybin ?

In this article we examine the metabolic processes that take place in the male body. We explain what a drug test looks for and how it works, and whether the use of psilocybin or other microdosingcan be seen.

Metabolism of psilocybin : how long do magic last mushrooms and truffles in your body?

If your magic mushrooms or truffles, your body reacts directly to the intake of psilocybin . Enzymes get to work converting it into the active metabolite psilocin . This is the psychoactive element that affects the serotonin receptors in the brain.

Most of the psilocybin you ingest is converted to psilocin within 1 hour of ingestion . This already occurs in significant quantities in your blood plasma after 20 to 40 minutes. Still, it takes about 80 to 100 minutes until you experience the peak of the effects.

After about 4 to 6 hours after ingestion, most of the psilocybin has disappeared from your body. You just pee out about 65%, while about 15 to 20% ends up in other stools and stays in it a little longer. The last 10 to 20% stays in your system a little longer.

The psilocin is converted to psilocin – O – glucuronide to leave the body in the urine. Keep in mind that this substance is much more stable than the psilocin itself, so that it can still be found in the urine even weeks after use.

How does a drug test work?

There are five different types of drug tests:

Urine tests
Blood tests
Saliva tests
Sweat tests
Hair tests

The urine test and hair test in particular can still detect substances for weeks after use. A drug test is used to look for five types of substances:

Oh piats
Phencyclidine (PCP)

This means that the use of magic mushrooms or truffle does not normally lead to a positive drug test. Keep in mind that new technologies may be developed to detect this use.

Can psilocybin be tested (and for how long)?

A standard drug test does not look for psilocybin or psilocin , so cannot determine intake. Keep in mind that there are less common tests that detect these substances. This is an in-depth test, which is more expensive and requires more effort. So keep in mind that psilocybin will not stay under the radar.

And, how long can the use of psilocybin be traced back? In most cases, this remains visible for a week on psilocin– O- glucuronide (in urine) based tests. A hair test even makes it possible to determine this up to 90 days after use.

Microdosing and drug testing: what do you need to know?

So far we’ve talked about a standard drug test and averages, based on use. But, what are the factors to consider when using psilocybin ?

In any case, it differs per person how your body reacts to psilocybin , and how long it can be found. Especially your height, weight, age, whether you (have ) smoked , alcohol consumption, the health of your kidneys and liver and any other conditions have an effect.

In addition, how often and how much psilocybin you use determines whether it shows up in a drug test, and for how long. The more you take, the longer it takes for your body to process it. That means you’ll test positive for longer on a drug test that can detect psilocybin .

The conclusion is that a standard drug test will not find out that you use Magic mushrooms or truffle with psilocybin . A specific test can detect this, both from your hair and from urine. In that case it is possible to find what you have used up to 90 days, so keep that in mind.

Can you safely combine microdosing with medicines or supplements?

Many users want to know if they can safely combine microdosing with their medication or supplements. It is one of the most frequently asked questions to researchers and experts in the field. To properly answer that question, researchers Dr. James Fadiman and Sophia Korb compiled a list of medications and supplements that have not been reported to cause problems when combined with microdosing.

The list is compiled from data reported in long-term studies of hundreds of participants around the world. They mainly used LSD, 1P-LSD and psilocybin. Please note that this does not guarantee that you can safely microdose with these medications or supplements. It is always important to handle this with care.

It is important to:

Consult with a general practitioner or doctor if you want to combine, stop or reduce the use of medicines.
To think that relatively little is known about microdosing. No one can advise you on this based on complete information. If you think that microdosing is a better alternative to your current medications, discuss this with your doctor and list the pros and cons together.


List of medications and supplements with no reported side effects so far:


Acetomenophen/paracetemol (Tylenol)
Dihydrocodeine (Co-dydramol )
Hydrocodone (Vicodin, Norco)
Ibuprofen (Advil, Motrin)
Naproxen (Aleve)
Tramadol (ultra)

Do not microdose when using Tramadol

Medicines for heart problems and high blood pressure

amiodarone (Cordarone, Nexterone)
hydrochlorothiazide (HCTZ, HCT)
lisinopril (Prinivil, Zestril)
losartan (Cozaar)
Spironolactone (Aldactone)
telemisartine (Micardis, Actavis)
valsartan (diovan)


Birth control

Hormonal pills



Ranitidine (Zantac)



clindamycin (Cleocin, Dalacin, Clinacin)
Minocycline (Minocin, Minomycin, Akamine)
Penicillin (Bicillin)


Antifungal agents

Fluconazole (Diflucan, Celozole)


Focus medication (ADHD/ADD)

Amphetamine (Adderall)
Bupropion (Wellbutrin)
Dextroamphetamine (Dexedrine, Metamina, Attentin, Zenzedi, Procentra, Amfexa)
Lisdexamfetamine (Vyvanse)
Methylphenidate (Ritalin, Biphentin)
Modafinil (Provigil)


To sleep

Zopiclone (Zimovane, Imovane)
Zolpidem (ambien, stilnox)



Cetirizine (Zyrtec)
Diphenahydramine (Benadryl, Gravol)
Loratadine (Claritin)
Ranitidine (Zantac)


Benzodiazepines (anxiety, sleep, seizures)

Alprazolam (Xanax)
Clonazepam (Klonopin)
Diazepam (Valium)
Flurazepam (Staurodorm)
Lorazepam (Ativan)


Other anxiolytics



Parkinson’s medication



Medications for high cholesterol

Atorvastatin (Lipitor)
Rosuvastatin (Crestor)
Simvastatin (Zocor)


Race tams



Mood stabilizers and antipsychotics

Aripiprazole (Abilify)
Buspirone (Buspar)
Lamotrigine (Lamictal)
Quetiapine (Seroquel)

Do not microdose when using Lithium

Diabetes mellitus

Metformin (Glucophage)



Baclofen (Lioresal)
Carbamazepine (Tegretol)
Cyclobenzaprine (Flexeril)
Sodium valproate
Tizanidine (Zanaflex)


Thyroid medication

Methimazole or thiamazole



Bupropion (Wellbutrin)
Citalopram (Celexa)
Desvenlafaxine (Pristiq)
Doxepin (Sinequan)
Duloxetine (Cymbalta)
Escitalopram (Lexapro)
Paroxetine (Paxil)
Sertraline (Zoloft)
Venlafaxine (Effexor)



Esomeprazole (Nexium)
Pantoprazole (Protonix)
Ranitidine (Zantac)


Breathing (asthma, COPD)

Salbutamol (Albuterol)
Cetirizine (Zyrtec)
Beclomethasone (Clenil Modulite)
Montelukast (singular)





Recreational drugs

Amphetamine (speed)
Marijuana (cannabis)



Mesalazine (Octasa)



Hydroxychloroquine (Quensyl)


Erectile Dysfunction

Tadalafil (Cialis)


Treatment of alcohol addiction

Acamprosate (Campral)
Disulfiram (Antabuse)


Hormones and steroids

Norethindrone Ethinyl Acetate
Prednisone (Deltasone, Liquid Pred, Orasone, Adasone, Deltacortisone)
Estrogen (Premarin)
Progesterone (Prometrium, Utrogestan, Endometrin)
Levothyroxine ( synthroid )



Spironolactone (Aldactone)



Bromelain _ _
Cafe ine _
Fish oil
Lemon balm
Lion’s mane
Methylsulfonylmethane (MSM)
Milk thistle
Mmega 3/6/9
passion flower
Skull cap
John’s wort
Turmeric (curcumin)
Turkey tail
Vitamin B6 , B12 , D3 , K , C , K2 , D


Newly added:

primidone (anticonvulsant)
topiramate (anticonvulsant)

Where can I track my order?

You can use your tracking number (provided by email) to find out the status of your shipment.
On our SHIPPING page you will find our tracking widget.

How long does the shipping take?

Shipping estimates are different for all countries, on our SHIPPING page will find more information about the estimated shipping time in business days.
Keep in mind that these days are not guaranteed because our shipping partners can run into delays in busy times. On our shipping page you can also track your order.

Which truffle do you sell?

GO Microdose does not sell psilocybin mushrooms. GO Microdose only sells the fresh sclerotia (underground substrate) from the Psilocybe Mexicana truffle. We specifically only sell fresh sclerotia (not dried, not extracted) because this is legal.

The Psilocybe Mexicana truffle can be freely cultivated, traded, and exported in the Netherlands.  It can also be freely provided to third parties in therapeutic sessions and be used for microdosing. It is a legal product in the Netherlands, as long as it has not undergone “active processing”, that’s why we only sell fresh sclerotia.

Therefore can be shipped to all EU countries under the European Commission’s Mutual Recognition of Goods Principle

To which countries do you ship?

We ship on a daily basis to almost all countries worldwide. This includes all EU countries, United Stated, United Kingdom and more. Is your country not available in our checkout? Please contact us, we might still ship there.

Which side effects has microdosing?

Microdosing has a few possible side effects:
• Fatigue
Some people experience more fatigue. It is quite possible that this is due to the extra impressions or the more active lifestyle that microdosing provides for them.

• Slight nausea
Nausea-like people experience a slight nausea. Sometimes it helps to take a little ginger so that this feeling disappears quickly.

• Tolerance
Tolerance may occur for some time. This means that your body is used to the effects. It is important to stop after a few days and start over again after a break, according to the step-by-step plan at the course that you follow.

• Hallucinations
Color blind people can suffer from hallucinations and ‘after images’. This only occurs with a small part of the people.

• Challenges in changes
Changes in your consciousness and sensitivity can lead to experienced challenges.

• Transpiration
Some people will transpire more if they use microdosings. That is not dangerous.

We therefore recommend that you stop microdosing for a month after 8 to 10 weeks of usage. You can then experience how you feel and what the differences are. Afterwards you can of course start again if you like.